CLOZAPINE (CLOZARIL)

Handling: 2 ML PLASMA COLLECTED IN EDTA (LAVENDER-TOP) DO NOT USE GEL BARRIER TUBES. FOR PLASMA, COLLECT BLOOD INTO LAVENDER-TOP TUBE. CENTRIFUGE AT 2000-2200 RPM (1000 G) AT 15-25 C FOR 8-10 MINUTES TO SEPARATE THE PLASMA. PIPET OR POUR THE PLASMA INTO POLYPROPYLENE OR POLYETHYLENE TUBES. SHIP AND STORE FROZEN. REFRIGERATION IS ACCEPTABLE FOR SHIPPING. FOR SERUM: COLLECT BLOOD INTO PLAIN RED-TOP TUBE. ALLOW TUBE TO STAND AT 15-28 C FOR 20-30 MINUTES FOR CLOTTING. CENTRIFUGE AT 2000-2200 RPM (1000 G) AT 15-25 C FOR 8-10 MINUTES TO SEPARATE THE SERUM. PIPET OR POUR SERUM INTO POLYPROPYLENE OR POLYETHYLENE TUBES. SHIP AND STORE AS ABOVE. OPTIMAL TIME TO COLLECT SAMPLE: 0.5-1 HOUR BEFORE NEXT ORAL DOSE AT STEADY STATE. (TIME TO STEADY STATE: 3-5 DAYS)., 1 ML PLASMA COLLECTED IN AN EDTA TUBE (LAVENDER-TOP), FROZEN